Vitamin D3 1 mil IU/G (w/ MCT Oil)

Bioactive Vitamin D3 for Skin Immunity and Barrier Repair

INCI Name: Cholecalciferol

A high-potency, oil-soluble Vitamin D3 (Cholecalciferol) designed for advanced cosmetic formulations. This essential vitamin plays a critical role in skin health by modulating immune responses, promoting cell differentiation, and providing potent antioxidant protection. Pre-dispersed in MCT oil for enhanced stability and bioavailability, it is an ideal active for products targeting barrier repair, skin rejuvenation, and overall resilience.

Solubility Notes:

Oil-soluble. Dispersed in MCT oil for easy incorporation into the oil phase of formulations. Add during the cool-down phase below 40°C and protect from UV exposure; suitable for emulsions within pH 4.5–6.5.

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Barrier Repair Creams

Strengthens the skin's natural defense system and supports lipid barrier integrity in formulations for compromised or sensitive skin.
Anti-Aging & Restorative Serums

Promotes healthy cell turnover and provides antioxidant defense against environmental stressors that contribute to premature aging.
Soothing Body Lotions

Helps to calm and balance the skin's immune response, making it ideal for body care products targeting dryness and irritation.
Night Repair Treatments

Works overnight to support the skin's natural repair and regeneration processes for a healthier, more resilient complexion.
Scalp Health Serums

Contributes to a balanced scalp environment by modulating inflammation and supporting healthy follicle function.
Post-Sun Care Products

Offers antioxidant benefits to help mitigate the effects of environmental damage in after-sun and restorative formulations.

Performance & Formulation Insights for Vitamin D3

How Vitamin D3 Works

Cholecalciferol, or Vitamin D3, is a pro-hormone that plays a vital role in nearly every organ, including the skin. Skin cells (keratinocytes) are unique in their ability to both synthesize Vitamin D3 from sun exposure and respond to it through Vitamin D Receptors (VDR). When applied topically, Vitamin D3 binds to these receptors, influencing gene expression related to cell growth, differentiation, and immunity. It helps regulate the orderly turnover of skin cells, reinforces the skin’s barrier function, and modulates the production of antimicrobial peptides, which are crucial components of the skin’s innate immune system. Its antioxidant properties also help neutralize free radicals, protecting skin from oxidative stress.

Formulation Guidelines

This Vitamin D3 is delivered in a stable, oil-based carrier (MCT Oil), which simplifies its use in anhydrous and emulsion-based systems. For optimal results, add it to the oil phase of your formulation. It is sensitive to high heat and UV light, so it should be incorporated during the cool-down phase at temperatures below 40°C. Maintain the final formulation pH between 4.5 and 6.5 to ensure stability. This active is compatible with other oil-soluble vitamins like Vitamin E (Tocopherol), which can help enhance its antioxidant stability, as well as with ceramides and fatty acids for comprehensive barrier support.

Key Formulation Benefits

Supports Skin’s Immune Function: Modulates the skin’s natural defense mechanisms, helping to create a healthy and balanced micro-environment.
Enhances Barrier Integrity: Promotes the proper differentiation of keratinocytes, essential for a strong and resilient epidermal barrier.
Potent Antioxidant: Helps protect the skin from environmental aggressors and oxidative stress that can lead to premature aging.
Promotes Skin Homeostasis: Supports regulated cell turnover and repair processes, contributing to overall skin health and appearance.
Oil-Soluble & Easy to Formulate: Pre-dispersed in MCT oil for excellent compatibility and stability in creams, lotions, and oils.
Ideal for Targeted Treatments: Suited for addressing dry, aging, or compromised skin in specialized facial and body care products.

Heading #1
Benefits	Antioxidants, Barrier Repair, Moisturizing & Hydration, Soothing & Anti-Inflammatory
INCI Name	Cholecalciferol
Usage Rate	0.1%-1%
Active Type	Vitamin D, Vitamins & Derivatives
Solubility	Oil-Soluble
Application Area	Body, Face, Scalp
Physical Form	Oil
Certifications	Cruelty-Free, Vegan

Frequently Asked Questions About Vitamin D3 1 mil IU/G (w/ MCT Oil)

The typical usage rate is between 0.1% and 1.0%. The concentration can be adjusted based on the product’s goal, with lower levels for daily maintenance and higher levels for targeted treatments.

As an oil-soluble ingredient, it is not directly soluble in water. To incorporate it into a water-based serum, an emulsifier or solubilizer is required to create a stable emulsion or micro-emulsion.

It binds to Vitamin D Receptors (VDR) in skin cells, which influences the expression of genes involved in cell differentiation, immune response, and barrier function. This helps regulate skin cell turnover and strengthens the skin’s natural defenses.

Yes, Vitamin D3 can degrade with exposure to high heat and UV light. It is recommended to add it to your formulation during the cool-down phase, below 40°C, and package the final product in opaque or UV-protective containers.

It can be formulated with other oil-soluble vitamins like E and K. When formulating with Vitamin C (often water-soluble and requiring a low pH) or Retinol, careful consideration must be given to the formulation type (e.g., emulsion, anhydrous) to ensure the stability and bioavailability of all actives.

The primary benefits include supporting the skin’s immune system, strengthening the epidermal barrier, providing antioxidant protection, and promoting healthy cell turnover. It is particularly beneficial for dry, mature, or compromised skin.

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