Dipotassium Glycyrrhizinate

High-Purity Licorice Root Active for Soothing and Brightening

INCI Name: Dipotassium Glycyrrhizate

Dipotassium Glycyrrhizinate is a high-purity active derived from licorice root, renowned for its potent anti-inflammatory and skin-soothing properties. It effectively reduces redness and irritation, making it ideal for sensitive or compromised skin. This versatile ingredient also helps to brighten the complexion and even skin tone by inhibiting pathways involved in melanin production. Its ability to preserve the skin’s natural hyaluronic acid content makes it an excellent addition to hydrating and anti-aging formulas.

Solubility Notes:

Soluble in hot water and alcohol. Add to the water phase of formulations, ideally below 60°C.

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Sensitive Skin Serums & Creams

Provides significant calming and anti-irritant effects to reduce redness and sensitivity in daily-use formulations.
Brightening Treatments & Spot Correctors

Helps fade the appearance of dark spots and post-inflammatory hyperpigmentation for a more even, radiant skin tone.
Soothing Toners & Mists

Delivers immediate relief for irritated skin in aqueous-based toners, after-sun care, and post-treatment products.
Eye Creams

Gently soothes the delicate eye area while helping to reduce the appearance of under-eye discoloration.
Barrier Repair Moisturizers

Supports skin barrier function by reducing inflammatory stress and preserving skin's natural hydration factors.
Scalp Health Treatments

Calms irritated and itchy scalps in serums and shampoos, helping to create a healthy environment for hair growth.

Performance & Formulation Insights for Dipotassium Glycyrrhizinate

How Dipotassium Glycyrrhizinate Works

Dipotassium Glycyrrhizinate (DPG) is the dipotassium salt of glycyrrhizic acid, the primary active isolated from licorice root (Glycyrrhiza glabra). It delivers potent anti-inflammatory and soothing action by modulating key inflammatory mediators, including prostaglandins and leukotrienes, to visibly reduce redness, itching, and irritation. Beyond calming benefits, DPG supports a brighter, more even complexion by helping to reduce the look of dark spots and post-inflammatory hyperpigmentation. It also inhibits hyaluronidase, the enzyme responsible for breaking down hyaluronic acid in the skin, thereby helping to preserve natural hydration, plumpness, and overall skin health.

Formulation Guidelines

Dipotassium Glycyrrhizinate is a white to off-white powder that is freely soluble in hot water and alcohol, making it easy to incorporate into the water phase of emulsions, gels, and aqueous solutions. Add to the water phase and heat gently, if necessary, to ensure complete dissolution. For optimal performance and stability, formulate between pH 5.0 and 6.0. Recommended usage levels range from 0.1% for daily soothing benefits up to 2.0% for intensive treatment products. DPG exhibits excellent compatibility with common cosmetic actives, including niacinamide, vitamin C derivatives, and hyaluronic acid.

Key Formulation Benefits

Potent Anti-Irritant: Effectively calms sensitive and reactive skin, ideal for redness-prone or compromised skin.
Skin Brightening: Helps improve tone and clarity by addressing discoloration and post-inflammatory marks.
Hydration Support: Helps preserve the skin’s natural hyaluronic acid by inhibiting hyaluronidase.
Antioxidant Defense: Provides antioxidant benefits to help protect against environmental stressors.
Excellent Stability: Performs well within a skin-friendly pH range of 5.0–6.0.
Versatile Application: Suitable for serums, moisturizers, eye creams, toners/mists, cleansers, and scalp treatments.

Heading #1
Benefits	Brightening & Skin Lightening, Dark Spot Reduction, Even Skin Tone, Hair & Scalp Care, Moisturizing & Hydration, Scalp Health, Soothing & Anti-Inflammatory
INCI Name	Dipotassium Glycyrrhizate
Usage Rate	0.1%-2%
Active Type	Botanical Extracts & Phytoactives, Licorice Derivatives
Solubility	Water-Soluble
Application Area	Body, Eye, Face, Lip, Scalp
Physical Form	Powder
Certifications	Cruelty-Free, Vegan

Frequently Asked Questions About Dipotassium Glycyrrhizinate

The typical usage rate is between 0.1% and 2.0%. Use 0.1–0.5% for general soothing in daily care products and 0.5–2.0% for targeted anti-inflammatory or brightening treatments.

Yes, it is exceptionally well-suited for sensitive skin. Its primary function is to soothe irritation and reduce redness, making it a cornerstone ingredient for calming formulations.

While not a direct acne treatment, its potent anti-inflammatory properties can significantly reduce the redness and irritation associated with acne blemishes and help minimize post-inflammatory hyperpigmentation.

By reducing inflammation that can trigger melanin production and supporting an even skin tone, it helps diminish the look of dark spots and discoloration.

The ideal pH range for stability and efficacy is 5.0–6.0.

Yes. It pairs well with niacinamide for barrier support and soothing, and with vitamin C derivatives for enhanced antioxidant and brightening effects.

Yes. It is a purified active component derived from the root of the licorice plant (Glycyrrhiza glabra).

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