Performance & Formulation Insights for AccessWHITE Arbutin
How Arbutin Works: Tyrosinase Inhibition
AccessWHITE Arbutin achieves its skin-brightening effects by targeting the primary enzyme responsible for melanin synthesis: tyrosinase. Arbutin’s molecular structure is similar to tyrosine, the natural substrate for this enzyme. When applied to the skin, arbutin acts as a competitive inhibitor, binding to the active site of tyrosinase. This blocking action prevents conversion of tyrosine into melanin precursors, effectively slowing and regulating pigment production. As a result, arbutin helps fade existing dark spots and prevents new ones from forming, promoting a clearer, more even skin tone—without the safety concerns associated with free hydroquinone.
Formulation Guidelines
AccessWHITE Arbutin is a crystalline powder readily soluble in water. For optimal results and stability, add it to the water phase during cool-down at temperatures below 40°C (104°F). It is stable across pH 3.5–6.6, with a recommended final formulation pH of 4.5–5.5 for maximum efficacy and skin compatibility. Arbutin pairs synergistically with other brightening agents such as Vitamin C derivatives and Niacinamide, and with exfoliants like AHAs that can enhance penetration and performance.
Key Formulation Benefits
- Clinically Proven Efficacy: Visibly reduces hyperpigmentation, including sun spots, age spots, and melasma.
- Safer Brightening Alternative: A glucoside of hydroquinone with a stronger safety profile and without permanent melanocyte damage.
- Excellent Stability: More stable than Kojic Acid and less pH-dependent than many Vitamin C derivatives for consistent performance.
- Versatile & Compatible: Easily incorporates into serums, creams, lotions, and masks; works well with Vitamin C derivatives, Niacinamide, and AHAs.
- Gentle on Skin: Generally well-tolerated for daily use and suitable for long-term brightening regimens.
- Antioxidant Properties: Offers secondary antioxidant support against environmental stressors contributing to uneven tone.