AccessPEP SKE

High-Performance Peptide for Visible Reduction of Expression Wrinkles

INCI Name: Dipeptide Diaminobutyroyl Benzylamide Diacetate, Aqua, Glycerin, Phenoxyethanol, Ethylhexylglycerin

AccessPEP SKE is a potent anti-wrinkle peptide that offers a topical, non-invasive alternative to procedures. Modeled on a synthetic tripeptide that mimics Waglerin 1, it helps relax facial muscles to visibly reduce the look of expression lines and deep wrinkles. Its targeted action makes it ideal for advanced anti-aging formulas that smooth and refine the skin’s surface.

Solubility Notes:

Water-soluble. Incorporate into the water phase or during the cool-down phase at temperatures below 40°C.

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Intensive Anti-Aging Serums

Delivers a concentrated dose to visibly smooth deep-set expression lines on the forehead and around the mouth.
Targeted Eye Creams

Effectively reduces the appearance of crow's feet and fine lines in the delicate eye area with its muscle-relaxing action.
Neck & Décolleté Creams

Helps to firm and smooth the skin on the neck and chest, areas prone to showing signs of aging.
Revitalizing Face Masks

Provides a rapid smoothing effect in wash-off or leave-on masks for an instantly refreshed and younger look.
Preventative Anti-Wrinkle Moisturizers

Incorporates into daily moisturizers to help prevent the formation of new expression lines caused by repeated facial movements.
Anti-Aging Hand Treatments

Revitalizes and smooths the skin on the hands, minimizing wrinkles for a more youthful appearance.

Performance & Formulation Insights for AccessPEP SKE

How Dipeptide Diaminobutyroyl Benzylamide Diacetate Works

AccessPEP SKE is a biomimetic peptide inspired by Waglerin 1, a peptide found in Temple Viper venom, designed to target the appearance of expression lines. Its mechanism is post-synaptic: it acts as an antagonist of the muscular nicotinic acetylcholine receptor (mnAChR). By binding to this receptor, it blocks the acetylcholine signal that triggers muscle contraction, keeping facial muscles in a more relaxed state. This targeted action helps visibly reduce dynamic wrinkles caused by repeated facial movements, leading to a smoother, more youthful-looking complexion.

Formulation Guidelines

Supplied as a clear, water-based solution, AccessPEP SKE is easy to incorporate into serums, gels, lotions, and creams. For optimal performance, formulate to a final pH of 4.0–6.5. Add to the water phase or during the cool-down stage below 40°C (104°F) to preserve peptide integrity. Recommended usage level is 2–5%. It is highly compatible with hyaluronic acid, antioxidants, and other peptides to build sophisticated, multi-functional anti-aging systems.

Key Formulation Benefits

Clinically Proven Efficacy: Demonstrates a significant reduction in the appearance of wrinkles and a measurable smoothing effect within weeks.
Targets Expression Lines: Especially effective on dynamic wrinkles such as crow’s feet, forehead lines, and nasolabial folds.
Needle-Free Alternative: A topical, non-invasive option often positioned as a “Botox-in-a-jar” concept for consumer appeal.
Formulation Friendly: Liquid format ensures easy, homogeneous incorporation and stability in a skin-friendly pH range.
Versatile Applications: Suitable for serums, gels, lotions, and creams across face and eye care.
Immediate & Ongoing Benefits: Helps deliver rapid smoothing while supporting longer-term, visible wrinkle reduction with continued use.

Heading #1
Benefits	Anti-Aging & Anti-Wrinkle, Eye Care, Wrinkle Reduction
INCI Name	Dipeptide Diaminobutyroyl Benzylamide Diacetate, Aqua, Glycerin, Phenoxyethanol, Ethylhexylglycerin
Usage Rate	2%-5%
Active Type	Anti-Wrinkle Peptides, Peptides
Solubility	Water-Soluble
Application Area	Body, Eye, Face
Physical Form	Liquid/Solution
Certifications	Cruelty-Free, Halal, Non-GMO, Vegan

Frequently Asked Questions About AccessPEP SKE

It is a synthetic peptide that mimics a compound in snake venom. It works post-synaptically as a muscular nicotinic acetylcholine receptor (mnAChR) antagonist, blocking the receptor to help keep facial muscles relaxed and reduce the formation of expression wrinkles.

The recommended concentration is 2–5% for optimal efficacy in anti-aging and anti-wrinkle cosmetic formulations.

Both are commonly positioned as neuro-peptides, but their mechanisms differ. Acetyl Hexapeptide-8 works pre-synaptically by disrupting the SNARE complex to reduce neurotransmitter release, while AccessPEP SKE works post-synaptically by blocking the muscle receptor itself. They can be combined for a complementary approach.

Yes. Dipeptide Diaminobutyroyl Benzylamide Diacetate has been evaluated for cosmetic use and is considered safe at the recommended concentrations, providing a topical effect without invasive procedures.

Formulate to a final pH between 4.0 and 6.5 to support peptide stability and performance.

Absolutely. It is an excellent choice for eye creams and serums, effectively targeting crow’s feet and other expression lines around the eyes.

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