AccessPEP PTP-5

High-Performance Collagen-Boosting Peptide for Skin Firmness and Wrinkle Reduction

INCI Name: Palmitoyl Tripeptide-5

AccessPEP PTP-5 features the powerful signal peptide Palmitoyl Tripeptide-5, designed to significantly boost collagen production within the skin. It works by mimicking the body’s own mechanism to activate TGF-β (Transforming Growth Factor-beta), the key factor in collagen synthesis. This action helps to rebuild the dermal matrix, resulting in visibly firmer skin, improved elasticity, and a reduction in the appearance of fine lines and wrinkles.

Solubility Notes:

Water-soluble. Add to the water phase during the cool-down stage below 40°C (104°F). Stable between pH 5.0 and 7.0.

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Anti-Aging Face Serums

Delivers a concentrated dose of peptide to stimulate collagen synthesis, improving skin texture and reducing wrinkle depth.
Firming & Lifting Creams

Enhances skin's structural integrity and elasticity in daily moisturizers, leading to a visibly firmer and more lifted appearance.
Eye Creams & Treatments

Targets wrinkles and loss of firmness in the delicate eye area, helping to smooth crow's feet and restore a youthful contour.
Body Firming Lotions

Improves skin tonicity and texture on the body, ideal for formulations targeting areas like the neck, décolleté, and arms.
Skin Repair & Post-Treatment Products

Supports the skin's natural repair processes, making it an excellent addition to formulas designed for damaged or aging skin.
Stretch Mark Treatments

Helps to rebuild the dermal matrix, improving the appearance of stretch marks by promoting new collagen formation.

Performance & Formulation Insights for AccessPEP PTP-5

How Palmitoyl Tripeptide-5 Works

AccessPEP PTP-5 is a biomimetic peptide that activates the skin’s own collagen synthesis pathways. Its mechanism centers on mimicking a specific sequence in the protein Thrombospondin I (TSP-1). This protein activates the latent but powerful Transforming Growth Factor-beta (TGF-β), which is universally recognized as a crucial element in the synthesis of new collagen. By activating TGF-β, Palmitoyl Tripeptide-5 signals dermal fibroblasts to ramp up collagen production. This process strengthens the skin’s extracellular matrix, effectively rebuilding its structural support system from within, which leads to a visible reduction in wrinkles and an increase in skin firmness.

Formulation Guidelines

This peptide is highly effective and easy to formulate with. For optimal results, a usage rate of 1–3% is recommended. AccessPEP PTP-5 is water-soluble and should be incorporated into the water phase of your formulation during the cool-down stage, at temperatures below 40°C (104°F), to protect the peptide’s structure and efficacy. It maintains stability within a pH range of 5.0 to 7.0, making it compatible with most standard cosmetic formulations. This peptide works synergistically with other anti-aging ingredients like hyaluronic acid, antioxidants, and other peptides.

Key Formulation Benefits

Clinically Proven Collagen Boost: Actively promotes the synthesis of new, healthy collagen, leading to measurable improvements in skin density and firmness.
Significant Wrinkle Reduction: Effectively diminishes the appearance of various types of wrinkles, from fine lines to deeper, more established ones.
Improves Skin Texture & Elasticity: Reinforces the dermal matrix to smooth the skin’s surface and restore youthful elasticity.
Excellent Stability & Compatibility: Easy to incorporate into aqueous systems and stable within a practical pH range for skin care.
Targeted Signal Action: Mimics the body’s own TSP-1 sequence to activate TGF-β, delivering a precise anti-aging mechanism.
Versatile Application: Suitable for facial serums, firming creams, eye treatments, and body care formulations.

Heading #1
Benefits	Anti-Aging & Anti-Wrinkle, Collagen Boosting, Firming & Lifting, Wrinkle Reduction
INCI Name	Palmitoyl Tripeptide-5
Usage Rate	1%-3%
Active Type	Anti-Wrinkle Peptides, Firming Peptides, Peptides
Solubility	Water-Soluble
Application Area	Body, Eye, Face
Physical Form	Powder
Certifications	Cruelty-Free, Vegan

Frequently Asked Questions About AccessPEP PTP-5

The recommended concentration is between 1% and 3% in the final formulation for optimal efficacy.

Palmitoyl Tripeptide-5 is a signal peptide that specifically activates TGF-β to drive collagen synthesis. Peptides in Matrixyl (Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7) are messenger peptides that signal skin repair through different pathways. They can be combined for a multi-faceted anti-aging approach.

Maintain formulations within pH 5.0–7.0 to ensure stability and bioavailability.

Yes, but formulating and usage timing matter. Consider using peptide products at a different time than low-pH acids (AHAs) or retinoids to avoid potential peptide degradation and to allow each active to perform at its optimal pH.

Yes. Multiple studies report significant increases in collagen synthesis and visible reductions in wrinkle depth versus placebo.

Absolutely. Its firming and wrinkle-reducing properties make it ideal for targeted eye creams and serums addressing crow’s feet and loss of firmness.

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