AccessPEP PPP-4

High-Performance Peptide for Collagen Boosting and Wrinkle Reduction

INCI Name: Palmitoyl Pentapeptide-4

AccessPEP PPP-4 features Palmitoyl Pentapeptide-4, a potent signal peptide that stimulates the synthesis of collagen I, III, IV, and elastin. By mimicking a fragment of procollagen, it cues fibroblasts to rebuild the skin’s extracellular matrix, leading to firmer, smoother skin and a visible reduction in fine lines and wrinkles. An ideal cornerstone for advanced anti-aging and skin repair formulations.

Solubility Notes:

Water-soluble. Add to the water phase of your formulation or during the cool-down phase below 40°C (104°F).

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Anti-Aging & Firming Serums

Provides a concentrated dose of peptides to boost collagen synthesis and improve skin elasticity and firmness.
Wrinkle Repair Creams

Integrates into daily moisturizers to visibly reduce the appearance of fine lines, crow's feet, and forehead wrinkles over time.
Eye Creams & Treatments

Targets the delicate eye area to firm skin and smooth expression lines safely and effectively.
Skin Repair & Regeneration Products

Supports skin’s natural repair mechanisms, ideal for post-treatment or mature skin formulations.
Collagen-Boosting Face Masks

Delivers an intensive treatment in sheet masks or rinse-off formulas to promote a plump, youthful complexion.
Body Firming Lotions

Helps improve skin texture and elasticity on the neck, decollete, and body.

Performance & Formulation Insights for AccessPEP PPP-4

How Palmitoyl Pentapeptide-4 Works

Palmitoyl Pentapeptide-4 is a matrikine (signal peptide) that mimics a fragment of human procollagen type I. When collagen degrades due to aging or environmental stress, the resulting peptide fragments signal fibroblasts to synthesize new matrix proteins. AccessPEP PPP-4 leverages this natural feedback loop: upon topical application, fibroblasts recognize the peptide and increase production of key extracellular matrix components including collagen I, III, IV, fibronectin, and elastin. This targeted stimulation rebuilds the skin’s structural framework from within, improving density, firmness, and visibly reducing wrinkle depth for smoother, more resilient skin.

Formulation Guidelines

AccessPEP PPP-4 is supplied as a user-friendly, water-soluble solution, eliminating the handling challenges of peptide powders. Incorporate into the water phase or add during the cool-down phase below 40°C (104°F) to maintain peptide integrity. It is stable between pH 4.0 and 7.0 and is compatible with most serum, gel, and emulsion systems. Recommended use level is 3% to 8% in the finished formula. For comprehensive age-defense systems, combine with synergists such as hyaluronic acid, vitamin C derivatives, niacinamide, and complementary peptides.

Key Benefits

Clinically Proven Wrinkle Reduction: Significantly diminishes the look of fine and deep wrinkles with consistent use.
Stimulates Multiple Collagen Types: Boosts synthesis of collagen I, III, and IV to enhance skin strength and resilience.
Improves Firmness & Elasticity: Encourages collagen and elastin production to restore youthful bounce and tone.
Refines Skin Texture: Promotes a smoother, more even surface over time.
Formulation-Friendly: Stable within skin-friendly pH; easily integrates into serums, gels, lotions, and creams.
Biomimetic, Targeted Action: Works with the skin’s natural signaling pathways for efficient, focused anti-aging benefits.

Heading #1
Benefits	Anti-Aging & Anti-Wrinkle, Collagen Boosting, Firming & Lifting, Wrinkle Reduction
INCI Name	Palmitoyl Pentapeptide-4
Usage Rate	3%-8%
Active Type	Anti-Wrinkle Peptides, Peptides
Solubility	Water-Soluble
Application Area	Body, Eye, Face
Physical Form	Liquid/Solution
Certifications	Cruelty-Free, Vegan

Frequently Asked Questions About AccessPEP PPP-4

The recommended usage rate is 3% to 8% in the finished formulation for meaningful anti-aging benefits.

Palmitoyl Pentapeptide-4 is a signal peptide that stimulates collagen and elastin production to rebuild skin structure. Neuropeptides typically target the appearance of expression lines by modulating muscle contractions. They act via different, complementary mechanisms and can be used together.

Yes, with thoughtful formulation. When using low-pH actives like AHAs, keep the final pH within 4.0–7.0. Many formulators stagger use (peptides in AM, acids/strong retinoids in PM) to maximize efficacy and comfort.

Initial texture improvements may appear sooner, but noticeable wrinkle reduction and firmer skin typically require 4–8 weeks of consistent use.

Yes. It is stable between pH 4.0–7.0 when protected from elevated temperatures (avoid >40°C) and formulated with standard good manufacturing practices.

Yes. It is a lab-synthesized peptide with no animal-derived components and is suitable for vegan formulations.

Contact An Expert

Only 4 fields to get started. An expert will respond within 1 business day.

Your Samples Are Waiting

You've selected the following samples:

You haven't added any samples yet! Visit our product pages to select samples you'd like to request. Once you've added samples, return here to complete your request.

Ready to try them out?

Log In

Cookie Notice

The website uses cookies to ensure you get the best experience on our website. View our Privacy Policy to learn more.