AccessPEP PP3

High-Performance Collagen-Boosting Peptide for Wrinkle Reduction

INCI Name: Aqua, Glycerin, Butylene Glycol, Carbomer, Polysorbate 20, Palmitate, Pentapeptide-4, Phenoxyethanol, Ethylhexylglycerin

AccessPEP PP3 is a powerful cosmetic active featuring Palmitoyl Pentapeptide-4, a renowned matrikine peptide that mimics a fragment of pro-collagen type I. It acts as a cellular messenger, stimulating fibroblasts to synthesize key components of the extracellular matrix, including collagen and fibronectin. This action helps rebuild the dermal structure, visibly reducing the depth of wrinkles and improving skin elasticity. It is an essential ingredient for advanced anti-aging and skin-firming formulations.

Solubility Notes:

Water-soluble. Incorporate into the water phase or during the cool-down phase of formulation below 40°C (104°F).

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Anti-Aging Serums

Provides targeted delivery to stimulate collagen production, effectively softening fine lines and deep-set wrinkles in potent, lightweight formulas.
Firming Face Creams & Moisturizers

Improves skin's structural integrity and elasticity, resulting in a firmer, more lifted appearance in daily-use creams for mature skin.
Eye Creams & Treatments

Safely and effectively targets crow's feet and fine lines in the delicate eye area, helping to restore a smoother, more youthful look.
Night Repair Products

Works synergistically with the skin's natural overnight repair cycle to rebuild the dermal matrix and diminish the signs of aging.
Collagen-Boosting Treatments

Acts as a primary active in targeted treatments and masks designed to enhance the skin's natural collagen and elastin levels.
Body Firming Lotions

Helps improve skin texture and firmness on the neck, décolleté, and body, addressing concerns of skin laxity.

Performance & Formulation Insights for AccessPEP PP3

How Palmitoyl Pentapeptide-4 Works

AccessPEP PP3 features the matrikine peptide Palmitoyl Pentapeptide-4, a five–amino acid sequence coupled to a palmitic acid chain to enhance skin penetration and stability. Biomimetically, it imitates a fragment of pro-collagen type I. When recognized by dermal fibroblasts, it acts as a signal to upregulate the synthesis of key extracellular matrix components—most notably collagen types I and III, fibronectin, and hyaluronic acid. By signaling that collagen breakdown has occurred, it initiates a reparative response that rebuilds the dermal matrix from within, visibly reducing wrinkle depth and restoring skin elasticity and firmness.

Formulation Guidelines

AccessPEP PP3 is a user-friendly aqueous solution that integrates seamlessly into serums, gels, lotions, and creams. For best results, add to the water phase or incorporate during the cool-down phase at temperatures below 40°C (104°F) to maintain peptide integrity. It is stable within a pH range of 4.0–7.0, compatible with most skin care systems. Combine with hyaluronic acid for hydration, antioxidants (e.g., Vitamin C derivatives) for protection, and complementary peptides for a comprehensive anti-aging strategy.

Key Formulation Benefits

Clinically Proven Efficacy: Palmitoyl Pentapeptide-4 is widely studied for reducing wrinkle depth and improving texture.
Stimulates Key Matrix Proteins: Boosts production of Collagen I & III and Fibronectin to reinforce dermal support.
Visible Wrinkle Reduction: Softens the look of fine lines and entrenched wrinkles, especially on the face and around the eyes.
Improves Firmness & Elasticity: Helps restore a lifted, resilient appearance by strengthening the dermal matrix.
Formulation-Friendly: Water-based solution integrates easily into serums, creams, and gels without compromising stability.
High Safety Profile: Well-tolerated for long-term use in anti-aging routines.

Heading #1
Benefits	Anti-Aging & Anti-Wrinkle, Collagen Boosting, Eye Care, Firming & Lifting, Wrinkle Reduction
INCI Name	Aqua, Glycerin, Butylene Glycol, Carbomer, Polysorbate 20, Palmitate, Pentapeptide-4, Phenoxyethanol, Ethylhexylglycerin
Usage Rate	2%-8%
Active Type	Anti-Wrinkle Peptides, Peptides
Solubility	Water-Soluble
Application Area	Body, Eye, Face
Physical Form	Liquid/Solution
Certifications	Cruelty-Free, Vegan

Frequently Asked Questions About AccessPEP PP3

The recommended usage rate is between 2% and 8%. For general anti-aging benefits, 2–5% is effective, while higher concentrations up to 8% can be used for more intensive treatment products.

Palmitoyl Pentapeptide-4 is a signal peptide that stimulates collagen production to rebuild the skin’s structure over time. Neuropeptides like Acetyl Hexapeptide-8 work by modulating nerve-to-muscle signaling to relax expression lines. They have different, complementary mechanisms.

AccessPEP PP3 uses the same active molecule, Palmitoyl Pentapeptide-4, originally commercialized as Matrixyl®, delivering proven anti-aging and collagen-boosting benefits.

This active is stable and effective in a pH range of 4.0 to 7.0, suitable for most skin care products.

Yes. It pairs well with Vitamin C derivatives and hydrating agents like hyaluronic acid. When used with retinol, it provides a complementary collagen-boosting effect.

Consistent use typically delivers visible improvements in texture and fine lines within 4–8 weeks, with more significant wrinkle reduction after 2–3 months.

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