Performance & Formulation Insights for AccessPEP POT
How Palmitoyl Oligopeptide Works
AccessPEP POT is a matrikine, a bioactive signal peptide that mimics a fragment of Type I collagen. When collagen degrades due to intrinsic aging or environmental stressors, small peptide fragments naturally signal fibroblasts to initiate repair. Palmitoyl Oligopeptide replicates this signal, prompting increased synthesis of collagen, elastin, and hyaluronic acid to rebuild the dermal matrix. The palmitoyl (C16) fatty acid attached to the peptide enhances stability and facilitates penetration through the skin’s lipid barrier, improving bioavailability and delivery to target fibroblasts.
Formulation Guidelines
This peptide integrates seamlessly into serums, emulsions, and treatment products. It is stable in a typical cosmetic pH range of 4.0–7.0. To preserve bioactivity, add AccessPEP POT during the cool-down phase below 40°C (104°F). It is compatible with most cosmetic ingredients and pairs synergistically with hyaluronic acid, vitamin C derivatives, niacinamide, ceramides, and soothing agents. Recommended usage is 2–5% in the finished formula to achieve visible improvements in firmness, elasticity, and wrinkle reduction.
Key Formulation Benefits
- Clinically Oriented Efficacy: Stimulates synthesis of collagen I/IV, elastin, and hyaluronic acid for measurable anti-aging results.
- Biomimetic Repair: Engages the skin’s natural signaling pathways to promote regeneration with excellent skin compatibility.
- Improves Skin Density: Helps increase dermal thickness, softens the look of wrinkles, and enhances resilience.
- Enhanced Hydration: Boosts endogenous hyaluronic acid for plumper, smoother, well-hydrated skin.
- Optimized Delivery: Palmitoyl modification improves peptide stability and penetration through the lipid barrier.
- Versatile & Compatible: Easy to incorporate into serums, creams, lotions, and targeted treatments without complex processing.