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AccessPEP NON1 PWD

High-Purity Brightening Peptide for Visible Dark Spot Reduction

INCI Name: Nonapeptide-1

AccessPEP NON1 PWD is a high-purity, powder form of Nonapeptide-1, a biomimetic peptide that combats hyperpigmentation by antagonizing the α-MSH/MC1 signaling pathway. By blocking the initial signal that triggers melanin production, it helps reduce the appearance of dark spots and supports a brighter, more even skin tone. Ideal for advanced brightening serums, spot correctors, and even-tone color cosmetics.

Solubility Notes:

Water-soluble. Pre-dissolve in the water phase and add during the cool-down phase (<40 °C) for optimal integrity.

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Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

  • Dark Spot Correcting Serums
    Provides a concentrated dose of Nonapeptide-1 to visibly reduce the appearance of age spots, sun spots, and post-inflammatory hyperpigmentation.
  • Skin Brightening Creams & Lotions
    Promotes a luminous, even skin tone in daily-use moisturizers for the face and body.
  • Brightening Facial Toners
    Integrates easily into aqueous solutions to prime the skin and deliver initial brightening benefits post-cleansing.
  • Even-Tone Powder Foundations
    Incorporates into anhydrous powder systems or emulsions to provide ongoing tone-correcting benefits alongside cosmetic coverage.
  • Targeted Hyperpigmentation Treatments
    Ideal for potent spot treatments that directly target localized areas of discoloration for intensive results.
  • Brightening Sheet Masks
    Delivers a powerful brightening boost in rinse-off or leave-on mask formats for immediate radiance.

Performance & Formulation Insights for AccessPEP NON1 PWD

How Nonapeptide-1 Works

AccessPEP NON1 PWD leverages Nonapeptide-1, a biomimetic peptide that targets the earliest biological trigger of melanogenesis. In skin, α-melanocyte-stimulating hormone (α-MSH) binds the MC1 receptor on melanocytes, initiating a cascade that activates tyrosinase and drives melanin synthesis. Nonapeptide-1 acts as an antagonist by competitively binding to the MC1 receptor, effectively blocking α-MSH from docking. By interrupting this upstream signal, it helps prevent both constitutive and UV-induced melanin production, visibly reducing hyperpigmentation and promoting a more even complexion.

Formulation Guidelines

AccessPEP NON1 PWD is a high-purity, water-soluble powder that offers excellent formulation flexibility. Dissolve it into the water phase during the cool-down stage at temperatures below 40 °C to maintain peptide integrity. It is stable in a typical cosmetic pH range of 4.0–7.0, with a recommended use level of 0.1%–2.5% depending on product format and target performance. For enhanced results, combine with complementary brightening actives such as Vitamin C derivatives and Niacinamide, and with gentle exfoliants like AHAs to support penetration and turnover.

Key Formulation Benefits

  • Targeted Mechanism: Offers a precise, upstream approach by blocking the hormonal trigger (α-MSH/MC1) for melanin production.
  • High Purity & Potency: Powder format delivers maximum potency and flexibility without added solvents or preservatives.
  • Proven Efficacy: Demonstrated ability to reduce hyperpigmentation and promote a brighter, more even skin tone.
  • Excellent Safety Profile: Gentle and well-tolerated for all skin types, including sensitive skin.
  • Versatile Application: Suitable for serums, toners, creams, masks, and color cosmetics.
  • Synergistic Action: Pairs well with Vitamin C derivatives, Niacinamide, and AHAs for multi-pathway tone correction.
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Benefits
Brightening & Skin Lightening, Dark Spot Reduction, Even Skin Tone, Tyrosinase Inhibition
INCI Name
Nonapeptide-1
Usage Rate
0.1%-2.5%
Active Type
Brightening Peptides, Peptides
Solubility
Water-Soluble
Application Area
Body, Face
Physical Form
Powder
Certifications
Cruelty-Free, Vegan

Frequently Asked Questions About AccessPEP NON1 PWD

The recommended usage rate is 0.1% to 2.5% in the final formulation, depending on product format and desired intensity.
Nonapeptide-1 blocks the upstream α-MSH signal at the MC1 receptor, preventing melanogenesis from initiating. Tyrosinase inhibitors like Arbutin act later in the pathway, and antioxidants like Vitamin C can help reduce existing melanin or oxidative triggers. It is an “upstream” inhibitor.
Yes. Combining with AHAs can be highly effective—the exfoliant aids removal of pigmented corneocytes while the peptide helps prevent new melanin formation.
Nonapeptide-1 is stable and effective between pH 4.0 and 7.0, aligning with most cosmetic systems.
It targets melanin overproduction, improving sun spots, age spots, and post-inflammatory hyperpigmentation (PIH).
Pre-dissolve in a portion of distilled water from the water phase, then add to the main batch during the cool-down phase below 40 °C with gentle mixing.

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