AccessPEP EGF PLUS

Q: What is the recommended usage rate for AccessPEP EGF PLUS?

The recommended usage rate is 1% to 5% in the final formulation. Use lower concentrations for daily maintenance products and higher concentrations for intensive repair treatments.

Q: How does a growth factor like EGF differ from other anti-wrinkle peptides?

Unlike many peptides that signal specific pathways (e.g., collagen synthesis), growth factors like EGF are larger proteins that bind directly to cell receptors to initiate broader activities including cell division, migration, and differentiation, resulting in comprehensive skin regeneration.

Q: Is this ingredient heat sensitive?

Yes. As a protein, sh-Oligopeptide-1 is heat-sensitive. Add during the cool-down phase below 40 °C (104 °F) to maintain bioactivity.

Q: What is the optimal pH range for formulations containing AccessPEP EGF PLUS?

For maximum stability and efficacy, maintain the final formulation pH between 5.5 and 7.5.

Q: Can this active be used with retinol or strong acids (AHAs/BHAs)?

It can be used in the same routine, but formulate in separate products or apply at different times. Low-pH acid formulas can degrade the growth factor, and retinol may increase irritation that counteracts EGF’s calming, regenerative benefits.

Q: Is sh-Oligopeptide-1 derived from human sources?

No. The “sh” denotes “synthetic human.” It is bio-engineered (typically via fermentation) to be bio-identical to human EGF and is free from animal and human-derived components.

High-Performance Growth Factor for Advanced Skin Regeneration and Repair

INCI Name: sh-Oligopeptide-1, Mannitol, Glycerol, EDTA, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin

AccessPEP EGF PLUS is a high-purity cosmetic active featuring sh-Oligopeptide-1, a bio-engineered Epidermal Growth Factor (EGF) designed for advanced skin regeneration. This powerful growth factor accelerates cell renewal and strengthens the skin’s natural barrier, leading to visibly improved elasticity and texture. It is highly effective in repairing environmental damage, reducing the appearance of scars, and promoting a resilient, youthful complexion. Supplied as a stable, easy-to-use solution, it is ideal for anti-aging serums, barrier repair creams, and post-procedure lotions.

Solubility Notes:

Water-soluble. Add during the cool-down phase (<40 °C / 104 °F) to protect peptide activity. Stable at pH 5.5–7.5.

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Skin Repair Serums

Delivers a concentrated dose of EGF to accelerate healing, repair sun damage, and reduce the appearance of fine lines and scars.
Anti-Aging Creams & Lotions

Integrates seamlessly into daily-use moisturizers to improve skin elasticity, firmness, and overall texture over time.
Barrier Repair Formulations

Strengthens the stratum corneum and enhances skin's natural defense mechanisms in creams designed for sensitive or compromised skin.
Post-Procedure Care

Promotes rapid and healthy skin recovery in formulations intended for use after chemical peels, microneedling, or laser treatments.
Scar & Blemish Treatments

Targets localized areas of damage to minimize the appearance of acne scars and post-inflammatory hyperpigmentation through cellular regeneration.
Intensive Treatment Masks

Provides a powerful regenerative boost in sheet masks and leave-on treatments, leaving skin visibly smoother and revitalized.

Performance & Formulation Insights for AccessPEP EGF PLUS

How Epidermal Growth Factor (EGF) Works

AccessPEP EGF PLUS harnesses sh-Oligopeptide-1, a synthetic, bio-identical Epidermal Growth Factor that binds to EGFR receptors on keratinocytes to trigger intracellular signaling. This cascade stimulates DNA synthesis and accelerates cell proliferation and differentiation, leading to faster skin turnover and enhanced wound repair. In cosmetic use, this activity supports increased collagen and elastin production, strengthening the skin barrier for improved elasticity, resilience, and a visible reduction in fine lines, photodamage, and textural irregularities.

Formulation Guidelines for Optimal Performance

This heat-sensitive active is supplied as an easy-to-use aqueous solution. To preserve bioactivity, add AccessPEP EGF PLUS in the cool-down phase at temperatures below 40 °C (104 °F). It is stable in formulations with a pH of 5.5–7.5; maintain your final pH within this range. Recommended usage is 1–5%, with lower levels for daily maintenance and higher levels for intensive repair. It is highly compatible with hydrating and barrier-support actives such as hyaluronic acid and niacinamide, as well as most non-signaling peptides, making it ideal for comprehensive anti-aging and skin repair systems.

Key Formulation Benefits

Accelerates Cell Regeneration: Promotes rapid skin renewal for anti-aging and post-procedure recovery.
Strengthens Skin Barrier: Enhances natural defenses for improved hydration and resilience to environmental stressors.
Improves Elasticity & Firmness: Encourages collagen and elastin support for smoother, firmer-looking skin.
Reduces Scars & Sun Damage: Aids tissue repair to minimize the look of scars, fine lines, and photodamage.
Biotech Purity & Safety: Fermentation-derived, non-animal origin for consistent quality and performance.
Easy to Formulate: Clear, water-soluble liquid integrates seamlessly into serums, lotions, and creams.

Heading #1
Benefits	Anti-Aging & Anti-Wrinkle, Barrier Repair, Moisturizing & Hydration, Skin Elasticity, Specialized Treatments, Wound Healing
INCI Name	sh-Oligopeptide-1, Mannitol, Glycerol, EDTA, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin
Usage Rate	1%-5%
Active Type	Biotech/Fermentation Actives, Fermented Ingredients, Growth Factors, Peptides
Solubility	Water-Soluble
Application Area	Body, Eye, Face
Physical Form	Liquid/Solution
Certifications	Cruelty-Free, Vegan

Frequently Asked Questions About AccessPEP EGF PLUS

The recommended usage rate is 1% to 5% in the final formulation. Use lower concentrations for daily maintenance products and higher concentrations for intensive repair treatments.

Unlike many peptides that signal specific pathways (e.g., collagen synthesis), growth factors like EGF are larger proteins that bind directly to cell receptors to initiate broader activities including cell division, migration, and differentiation, resulting in comprehensive skin regeneration.

Yes. As a protein, sh-Oligopeptide-1 is heat-sensitive. Add during the cool-down phase below 40 °C (104 °F) to maintain bioactivity.

For maximum stability and efficacy, maintain the final formulation pH between 5.5 and 7.5.

It can be used in the same routine, but formulate in separate products or apply at different times. Low-pH acid formulas can degrade the growth factor, and retinol may increase irritation that counteracts EGF’s calming, regenerative benefits.

No. The “sh” denotes “synthetic human.” It is bio-engineered (typically via fermentation) to be bio-identical to human EGF and is free from animal and human-derived components.

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