AccessPEP AOT-3 sol.

High-Performance Peptide for Expression Line Reduction

INCI Name: Aqua, Acetyl Octapeptide-3, Phenoxyethanol, Ethylhexylglycerin

AccessPEP AOT-3 sol. is an advanced anti-wrinkle active featuring Acetyl Octapeptide-3, an elongated peptide designed to offer enhanced efficacy in reducing expression lines. As a next-generation evolution of hexapeptides, it effectively targets the mechanism of muscle contraction, helping to relax the skin and visibly smooth deep-set wrinkles like crow’s feet and forehead lines. This makes it a powerful, non-invasive alternative for high-performance anti-aging formulations.

Solubility Notes:

Water-soluble, add to the water phase or during cool-down below 40°C.

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Advanced Anti-Aging Serums

Delivers a potent dose of octapeptide to visibly relax and smooth deep expression lines on the forehead and around the mouth.
High-Performance Eye Creams

Specifically targets and reduces the appearance of crow’s feet and dynamic wrinkles in the delicate eye contour area.
Forehead & Frown Line Treatments

Ideal for concentrated spot treatments that directly address the wrinkles caused by repeated facial expressions.
Lifting & Firming Moisturizers

Incorporates into daily-use creams to provide a continuous relaxing effect on facial muscles, preventing the deepening of expression lines.
Professional Treatment Masks

Boosts the efficacy of sheet masks and rinse-off treatments for an immediate, visible smoothing and plumping effect.
Age-Defense Primers

Creates a smoother canvas for makeup application by minimizing the appearance of fine lines and wrinkles in cosmetic primers.

Performance & Formulation Insights for AccessPEP AOT-3 sol.

How Acetyl Octapeptide-3 Works

AccessPEP AOT-3 sol. features Acetyl Octapeptide-3, an advanced peptide that functions as a potent muscle-relaxing active. It is an elongation of the well-known Acetyl Hexapeptide-8. Its mechanism of action is based on competitively inhibiting the formation of the SNARE protein complex. By mimicking the N-terminal end of the SNAP-25 protein, it destabilizes the complex, which in turn reduces the release of acetylcholine (ACh) at the neuromuscular junction. This attenuation of neurotransmitter release leads to a reduction in the intensity of facial muscle contractions, thereby relaxing expression lines and visibly smoothing the skin’s surface. It is considered a more potent topical alternative for targeting dynamic wrinkles.

Formulation Guidelines

This active is supplied as a standardized, easy-to-use aqueous solution, ensuring straightforward incorporation into the water phase of cosmetic formulations. To maintain peptide integrity, it should be added during the cool-down phase of the manufacturing process, at temperatures below 40°C (104°F). AccessPEP AOT-3 sol. is stable within a pH range of 4.0 to 7.0, making it compatible with most standard skin care formulations. It pairs exceptionally well with other anti-aging actives, such as hyaluronic acid for hydration and collagen-boosting peptides for a multi-faceted approach to skin rejuvenation.

Key Benefits

Advanced Wrinkle Reduction: Offers a more potent action against expression lines compared to first-generation peptides, providing visible results on crow’s feet, forehead lines, and nasolabial folds.
Targeted Expression Line Smoothing: Specifically designed to address wrinkles formed by repetitive facial movements, making it highly effective for dynamic wrinkle treatment.
Non-Invasive Topical Solution: Provides a compelling, needle-free alternative for consumers seeking to achieve smoother, more relaxed-looking skin without invasive procedures.
Excellent Formulation Compatibility: As a water-soluble solution, it is simple to formulate into serums, gels, lotions, and creams without complex solubilization steps.
Proven Safety for Eye Area: Well-tolerated and ideal for use in targeted eye contour products where expression lines are a primary concern.
Synergistic Anti-Aging Effects: Combines effectively with other ingredients like signal peptides, antioxidants, and hydrators to create comprehensive and powerful anti-aging products.

Heading #1
Benefits	Anti-Aging & Anti-Wrinkle, Eye Care, Wrinkle Reduction
INCI Name	Aqua, Acetyl Octapeptide-3, Phenoxyethanol, Ethylhexylglycerin
Usage Rate	3%-10%
Active Type	Anti-Wrinkle Peptides, Peptides
Solubility	Water-Soluble
Application Area	Eye, Face
Physical Form	Liquid/Solution
Certifications	Cruelty-Free, Vegan

Frequently Asked Questions About AccessPEP AOT-3 sol.

The recommended concentration is between 3% and 10%. Use lower levels (3-5%) for daily maintenance products and higher levels (5-10%) for intensive serums and targeted treatments.

Acetyl Octapeptide-3 is an elongated version of Acetyl Hexapeptide-8, containing eight amino acids instead of six. This structural difference is believed to enhance its ability to interfere with the SNARE complex, offering potentially greater efficacy in relaxing muscle contractions.

It works by mimicking a protein involved in muscle contraction (SNAP-25) and destabilizing the SNARE complex. This reduces neurotransmitter release, which in turn lessens the intensity of facial muscle contractions that lead to expression lines.

Yes, it is compatible with most cosmetic ingredients. When formulating with actives that require a specific pH, like L-Ascorbic Acid, ensure the final formula’s pH remains in the stable range for the peptide (4.0-7.0). For maximum efficacy, it is often recommended to use peptides in a separate AM routine and retinol in a PM routine.

This peptide remains stable and effective in formulations with a final pH between 4.0 and 7.0.

Absolutely. Its mechanism is perfectly suited for addressing crow’s feet and other dynamic wrinkles around the eyes, and it has a strong safety profile for use in this delicate area.

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