AccessPEP AOT-3 PWD

High-Performance Anti-Wrinkle Peptide for Deep Expression Lines

INCI Name: Acetyl Octapeptide-3

AccessPEP AOT-3 PWD is a high-purity, powder form of Acetyl Octapeptide-3, an advanced biomimetic peptide designed to combat deep expression lines. As an elongation of Acetyl Hexapeptide-8, it offers enhanced efficacy in reducing the muscle contractions that lead to wrinkles. By interfering with the SNARE protein complex, it visibly smooths crow’s feet, forehead lines, and other dynamic wrinkles, making it an essential active for high-performance anti-aging formulations.

Solubility Notes:

Water-soluble. Dissolve in the water phase of your formulation during the cool-down stage (below 40°C).

Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

Intensive Anti-Aging Serums

Provides a concentrated dose to effectively target and relax deep-set expression lines on the forehead and around the mouth.
Advanced Eye Creams

Specifically targets and smooths crow's feet and fine lines in the delicate eye contour area with proven efficacy.
Targeted Wrinkle Treatments

Ideal for spot treatments and corrector pens designed to deliver potent wrinkle-relaxing benefits directly to problem areas.
Firming & Lifting Moisturizers

Integrates into daily-use creams and lotions to provide a continuous relaxing effect on facial muscles, preventing the formation of new lines.
Professional Anti-Wrinkle Masks

Boosts the performance of rinse-off or leave-on facial masks for an immediate, visible smoothing and plumping effect.
Cosmetic Drone Formulations

Can be incorporated into advanced delivery systems to enhance penetration and target specific cellular pathways for maximum efficacy.

Performance & Formulation Insights for AccessPEP AOT-3 PWD

How Acetyl Octapeptide-3 Targets Expression Wrinkles

AccessPEP AOT-3 PWD features Acetyl Octapeptide-3, often considered a next-generation evolution of Acetyl Hexapeptide-8. Its mechanism of action is a targeted disruption of the neuromuscular signaling that causes facial muscles to contract. The peptide mimics the N-terminal end of the SNAP-25 protein, allowing it to compete for a position within the SNARE complex. By destabilizing this complex, the peptide effectively reduces the release of neurotransmitters (catecholamines) that trigger muscle contractions. This leads to a relaxation of facial muscles, which softens the appearance of existing expression lines and helps prevent the formation of new ones. It offers a topical, non-invasive approach to achieving results similar to those of botulinum toxin.

Formulation Guidelines for Optimal Stability & Efficacy

As a high-purity powder, AccessPEP AOT-3 PWD offers formulation flexibility and potency. To ensure the peptide’s integrity, it should be incorporated during the cool-down phase of manufacturing, at temperatures below 40°C (104°F). First, pre-dissolve the powder in a portion of the formulation’s water phase before adding it to the main batch. This active is stable and effective across a broad pH range of 3.0 to 8.0, making it compatible with a wide variety of cosmetic bases. It works synergistically with other anti-aging ingredients like hyaluronic acid, collagen-boosting peptides, and antioxidants.

Key Formulation Benefits

Enhanced Potency: As an elongated chain of Argireline, Acetyl Octapeptide-3 is recognized for providing a more pronounced reduction in the depth and appearance of wrinkles.
Targeted Action: Specifically addresses wrinkles caused by facial expressions, such as crow’s feet, glabellar lines (between the eyebrows), and forehead furrows.
High Purity Powder: The powder format ensures no dilution with preservatives or additives, allowing for higher concentration and greater formulation control.
Excellent Stability: Maintains its efficacy across a wide pH range (3.0–8.0), ensuring stability in various serum, gel, and emulsion systems.
Botox-in-a-Jar Marketing: Provides a powerful marketing story as a safe, topical, and non-invasive alternative to injectable treatments for expression lines.
Synergistic Potential: Combines seamlessly with other anti-aging actives, including signaling peptides and antioxidants, to create comprehensive and powerful age-defying products.

Heading #1
Benefits	Anti-Aging & Anti-Wrinkle, Eye Care, Wrinkle Reduction
INCI Name	Acetyl Octapeptide-3
Usage Rate	3%-10%
Active Type	Anti-Wrinkle Peptides, Peptides
Solubility	Water-Soluble
Application Area	Eye, Face
Physical Form	Powder
Certifications	Cruelty-Free, Vegan

Frequently Asked Questions About AccessPEP AOT-3 PWD

The recommended concentration is between 3% and 10%. Use lower levels for daily maintenance products and up to 10% for intensive, targeted treatment serums.

Acetyl Octapeptide-3 is an elongation of Acetyl Hexapeptide-8. It functions via the same SNARE complex inhibition mechanism but is often considered to have a stronger muscle-relaxing effect, leading to a more significant reduction in wrinkle depth.

For best results, pre-disperse the powder in a small amount of distilled water or another aqueous component of your formula. Add this solution during the cool-down phase (below 40°C) with gentle mixing to ensure the peptide’s structural integrity is not compromised by heat.

Yes, AccessPEP AOT-3 PWD is stable in a pH range of 3.0–8.0, making it compatible with well-formulated products containing L-Ascorbic Acid or AHAs. However, for maximum stability of all actives, it’s often best to formulate at a pH that is optimal for the entire system, typically between 4.5 and 6.5.

Yes, Acetyl Octapeptide-3 is widely used in eye cream formulations to specifically target crow’s feet and has a strong safety profile for this application.

While individual results vary, visible smoothing of fine lines can often be observed within 2–4 weeks of consistent, twice-daily use at effective concentrations (5–10%).

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