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AccessCARE RET 4.5

4.5% Encapsulated Retinol for Controlled-Release Anti-Aging Performance

INCI Name: Water, Caprylic/Capric Triglyceride, Macadamia Ternifolia Seed Oil, Butylene Glycol, Hydrogenated Lecithin, Polysorbate 20, Retinol, Brassica Campestris (Rapeseed) Sterols, Glycerin, 1,2-Hexanediol, Cholesterol, Ceteth-3, Ceteth-5, Aluminum/Magnesium Hydroxide Stearate, Tocopherol, Potassium Cetyl Phosphate, Disodium EDTA

AccessCARE RET 4.5 is a 4.5% Retinol active built on Vivify’s 3-step encapsulation technology, engineered to protect this notoriously unstable Vitamin A derivative from heat, light, and oxidation while enabling controlled release and enhanced skin penetration. Controlled studies show +60% enhanced skin penetration alongside strong stability retention — 95% Retinol survival after 1 month and 85% after 3 months.

Solubility Notes:

Delivered as a water-based liposomal dispersion; both/dual-soluble due to encapsulation. Add to the water phase; avoid high heat or high-shear processing that could compromise the liposomal structure.

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Perfect For These Applications

Other cosmetic uses possible—contact us for formulation guidance.

  • Anti-Aging Serums & Treatments
    Core retinol delivery for fine-line and texture claims, leveraging stabilized actives and enhanced penetration.
  • Night Creams & Renewal Treatments
    Controlled-release encapsulation suits overnight use, supporting active integrity away from light/oxidative exposure.
  • Sensitive-Skin Retinol Formulations
    Encapsulation moderates direct retinol exposure, supporting improved tolerability versus unencapsulated retinol.
  • Multi-Active Anti-Aging Systems
    Stabilized retinol pairs with peptides, antioxidants, and other actives without compromising potency.

Performance & Formulation Insights

How It Works: Vitamin A actives like Retinol are highly sensitive to UV, heat, and oxidation, and also present penetration and irritation challenges in raw form. RET 4.5 addresses this with a 3-step encapsulation process: Retinol is first encapsulated within Layered Double Hydroxide (LDH); a second liposome process then forms Multi-Lamellar Vesicles (MLV) that mimic native skin lipid structures; finally, the two encapsulation systems are combined for enhanced protection and delivery.

Formulation Guidelines

Dose based on the 4.5% Retinol concentration of the complex to reach your target finished-product Retinol percentage. Incorporate into the water phase; because the active is pre-encapsulated, avoid excessive heat or high-shear processing. Standard Vitamin A precautions (opaque/airless packaging, antioxidant co-actives) remain good practice even with encapsulation.

Key Formulation Benefits:

  • Enhanced Stability: 95% Retinol survival after 1 month, 85% after 3 months, under controlled conditions.
  • Enhanced Skin Penetration: +60% enhanced skin penetration versus unencapsulated Retinol.
  • Controlled, Skin-Mimetic Delivery: MLV structures mimic native skin lipids for controlled release and improved tolerability.
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Benefits
Anti-Aging & Anti-Wrinkle, Antioxidants, Skin Elasticity, Wrinkle Reduction
INCI Name
Water, Caprylic/Capric Triglyceride, Macadamia Ternifolia Seed Oil, Butylene Glycol, Hydrogenated Lecithin, Polysorbate 20, Retinol, Brassica Campestris (Rapeseed) Sterols, Glycerin, 1,2-Hexanediol, Cholesterol, Ceteth-3, Ceteth-5, Aluminum/Magnesium Hydroxide Stearate, Tocopherol, Potassium Cetyl Phosphate, Disodium EDTA
Usage Rate
0.22%-22.22%
Active Type
Vitamin A (Retinoids/Retinol), Vitamins & Derivatives
Solubility
Both/Dual-Soluble
Application Area
Face
Physical Form
Liquid/Solution
Certifications

Frequently Asked Questions About AccessCARE RET 4.5

Via 3-step encapsulation (LDH primary liposome, MLV secondary liposome, combined final encapsulation), yielding 95% Retinol survival after 1 month and 85% after 3 months.
Dose based on the 4.5% Retinol concentration of the complex to hit your target finished-product Retinol percentage.
The controlled-release, skin-mimetic delivery system is designed to support improved tolerability versus unencapsulated retinol, though individual sensitivity testing is still recommended.

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AccessCARE RET 4.5

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